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Our Culture

If you are considering a job with us, please take a few minutes to review our values. Operating with Integrity, Respect, Quality and Innovation are non-negotiable. At Obsidian, we embody the following values (obviously, we have a thing for alliterations):

Adaptability & Agility

We catalyze our evolution through continuous learning and sharing

Efficiency & Efficacy

We maximize our capabilities by leveraging each other’s expertise

Passion & Purpose

Our patients are waiting

Resilience & Results

We tenaciously overcome challenges to deliver meaningful outcomes

Camaraderie & Chemistry

We celebrate trust and community

 

“Obsidian provides the opportunity to collaborate in teams, with an open exchange of ideas and learnings. This transparency and curiosity fosters individual professional development while advancing the team toward developing new therapeutics with the potential to impact patient lives.”


Jennifer Gori, Ph.D.
Director of Program Strategy
 

We always welcome dedicated and talented applicants to apply to join our growing team. Please send resumes to jobs@obsidiantx.com; include a cover letter that highlights your qualifications and matches our requirements.

Open Positions

Sr. Scientist, Cell Therapy

About the Company:

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s lead programs are in adoptive immune cell therapy, applying our cytoDRiVE™ technology to control the expression of proteins for enhanced therapeutic efficacy and safety.

We are looking for a talented, flexible, collaborative, dynamic scientist to join the department of Cell Therapy as key contributors to preclinical research supporting Cell Therapy program research and development.

This role is a unique opportunity to at a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced biotech team. You will help us to continue to build a transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

Primary Responsibilities:

  • Lead preclinical proof of concept research activities toward the development of cell therapy products
  • Mentor and/or mentor a team of scientists/research associates in the design, execution and analysis of experiments that support programs
  • Design, develop and apply cell-based immune assays, including engineering of human T and NK cells
  • Make independent, intellectual, and technical contributions to projects, while working on a collaborative team
  • Isolate immune cells from human blood and tissue and conduct ex vivo engineering, differentiation, characterization, and/or in vivo adoptive cell transfer studies
  • Independently design experiments, meticulously execute bench work, troubleshoot assays, analyze data, and communicate findings
  • Present results at internal meetings

Required Qualifications and Preferred Skills:

  • PhD in Immunology or a related field with 3+ years of industry experience
  • Ability to quickly learn and adapt to fast paced, rapidly changing start-up environment
  • Scientific rigor in the design, execution, analysis, and troubleshooting of scientific experiments
  • Experience leading and driving research projects
  • Highly motivated team contributor, with ability to work independently and collaboratively
  • Excellent organization, record keeping, multi-tasking, and communication skilled
  • Demonstrated expertise in ex vivo immunology methods including T and NK cell genetic engineering (gene transfer or gene editing), functional assay development using techniques such as multi-color flow cytometry, cytotoxicity assays, cytokine quantitation
  • Experience with tumor infiltrating lymphocytes (TIL) preferred
  • Viral vector transduction of primary human immune cells preferred
  • Cellular immunotherapy experience preferred
  • Authorized to work in the US at the time of application
Associate Director, Cell Therapy

About the Company:

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s lead programs are in adoptive immune cell therapy, applying our cytoDRiVE™ technology to control the expression of proteins for enhanced therapeutic efficacy and safety.

We are looking for a talented, experienced scientific leader to join the department of Cell Therapy as a key contributor to preclinical research supporting Cell Therapy program research and development. As an Associate Director at Obsidian, you will have a key leadership and a program-based role.  This role will require both matrix management and program research leadership.

This role is a unique opportunity to at a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced biotech team. You will help us to continue to build a transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

Primary Responsibilities:

  • Lead preclinical proof of concept research activities toward the development of cell therapy products
  • Mentor and/or mentor a team of scientists/research associates in the design, execution and analysis of experiments that support programs
  • Design, develop and apply cell-based immune assays, including engineering of human TIL and NK cells
  • Make independent, intellectual, and technical contributions to projects, while working on a collaborative team
  • Isolate immune cells from human blood and tissue and conduct ex vivo engineering, differentiation, characterization, and/or in vivo adoptive cell transfer studies
  • Independently design experiments, meticulously execute bench work, troubleshoot assays, analyze data, and communicate findings
  • Present results at internal and external meetings

Required Qualifications and Preferred Skills:

  • PhD in Immunology or a related field with 3+ years of experience postdoctoral training, strong publication record, and preference for 7+ years of industry experience
  • Ability to quickly learn and adapt to fast paced, rapidly changing start-up environment
  • Scientific rigor in the design, execution, analysis, and troubleshooting of scientific experiments
  • Experience leading and driving research projects to IND
  • Highly motivated team contributor, with ability to work independently and collaboratively
  • Excellent organization, record keeping, multi-tasking, and communication skilled
  • Demonstrated expertise in ex vivo immunology methods including T and NK cell genetic engineering (gene transfer or gene editing), functional assay development using techniques such as multi-color flow cytometry, cytotoxicity assays, cytokine quantitation
  • Experience with tumor infiltrating lymphocytes (TIL) preferred
  • Viral vector transduction of primary human immune cells preferred
  • Cellular immunotherapy experience preferred
  • Authorized to work in the US at the time of application
Senior Research Associate/Associate Scientist (New Technology Discovery)

About the Company:

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety.

 

Scope:

We are looking for a highly motivated Senior Research Associate or Associate Scientist with expertise in synthetic biology and cell engineering to join our Discovery team.  The successful candidate will be responsible for the engineering and testing of new technologies for regulating gene expression as part of a team developing Obsidian’s next generation CytoDriveTM platform.  The candidate will work alongside a multidisciplinary team of immunologists, cell biologists, and molecular biologists to deliver controllable cellular therapies. This role is a unique opportunity to be a scientific contributor in a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced startup team. You will help us build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

 

Key Responsibilities:

  • Engineer cell lines with regulated gene expression systems using a range of delivery methods including transfection, viral transduction, and homology directed repair.
  • Develop assays to test performance of engineered cell lines using state of the art techniques including NGS, microscopy, quantitative PCR, western blot, ELISA, and FACS
  • Design, plan, and execute experiments to test performance of regulated gene expression systems in relevant pre-clinical models of disease working both independently and as part of a multidisciplinary team of researchers
  • Interpret results, troubleshoot technical hurdles, and propose solutions to the team
  • Maintain excellent records of experiments
  • Collaborate effectively across Obsidian organization, present internally to project teams, management and scientific teams.

 

Minimum Qualifications:

  • Bachelor’s or Master’s degree in biology or relevant field with Masters and 2+ years of experience or Bachelor’s and 5+ years of experience in biotech/pharma setting
  • Tissue culture of adherent and suspension cell lines, including transfection and viral transduction
  • Experience with genome editing and associated analytical methods.
  • Analysis of sequencing data using Benchling, DNAstar, Geneious, or similar informatics software
  • Molecular/biochemical assays for cell line analysis such as quantitative PCR, western blot, ELISA, and FACS
  • Strong troubleshooting and communication skills, highly organized with strong record keeping and an ability multi-task
  • Highly collaborative working style and ability to adapt in a fast paced, rapidly developing environment

 

Preferred Qualifications:

  • Experience working in the cell and gene therapy field is highly desirable.
  • Previous experience in synthetic biology or regulated gene expression
  • Engineering primary cells by viral and/or non-viral gene delivery
Associate Scientist/ Senior Associate Scientist (Vector Technologies)

About the Company:

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety.

 

Scope:

We are looking for a highly motivated Senior Research Associate or Associate Scientist with expertise in viral vector production to join our Vector Technologies team.  The successful candidate will be part of a team responsible for developing and running viral vector production to support engineered regulatable cell therapies. The candidate will work collaboratively in the Center of Excellence with Analytical Technologies, Cell Technologies, and Protein Technologies to enable next generation controllable cellular therapies. This role is a unique opportunity to be a scientific contributor in a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced startup team. You will help us build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

 

Key Responsibilities:

  • Maintain cell cultures and cell banks; produce, concentrate, and characterize lentiviral and retroviral vectors for gene delivery into cell lines and primary cells.
  • Measure viral titer in engineered cell lines using quantitative PCR and FACS
  • Design, plan, and execute experiments to test performance of regulated gene expression systems working both independently and as part of a multidisciplinary team of researchers
  • Interpret results, troubleshoot technical hurdles, and propose solutions to the team
  • Maintain excellent records of experiments
  • Collaborate effectively across Obsidian organization, present internally to project teams, management, and scientific teams

 

Minimum Qualifications:

  • Bachelor’s or Master’s degree in biology or relevant field with Masters and 2+ years of experience or Bachelor’s and 5+ years of experience in biotech/pharma setting
  • At least 2 yrs experience with viral (lentivirus and retrovirus) gene transfer strategies and stable cell line production. Experience with transducing primary human T- cells a plus.
  • Tissue culture of adherent and suspension cell lines, including transfection and viral transduction
  • Molecular/biochemical assays for cell line analysis such as quantitative PCR, western blot, ELISA, and FACS
  • Strong troubleshooting and communication skills, highly organized with strong record keeping and an ability multi-task
  • Highly collaborative working style and ability to adapt in a fast paced, rapidly developing environment

 

Preferred Qualifications:

  • Experience working in the cell and gene therapy field is highly desirable
  • Experience in immunology / immuno-oncology is strongly preferred
  • Engineering primary cells by viral and/or non-viral gene delivery
Senior/ Principal Scientist Vector Technologies

Obsidian Therapeutics is pioneering controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases. We are looking for a leader in our Technologies Center of Excellence to develop Vector Technology capabilities for Obsidian driving the development of the engineered cell therapy products in our pipeline targeting cancer. You will be a vital part of helping to achieve the Obsidian’s vision by collaboratively translating innovative science into medical breakthroughs for patients.

 

Scope:

The Senior Scientist/ Principal Scientist in Vector Technologies is a key leadership role within our Technologies Center of Excellence function and will be responsible for leading the Vector Technologies group.  The Technologies Center of Excellence has the mission of advancing product development by delivering critical capabilities in core technologies and key reagents. The Vector Technologies group is responsible for providing gene delivery production protocols and materials for the development of engineered cell therapies. The individual in this role will work collaboratively with the Analytical technologies, Cell technologies and Protein technologies groups to develop scalable and efficient viral vector production processes to support the Cell Therapy teams. You will have significant opportunity to have an impact to Obsidian’s broader development strategies and efforts.

Key Responsibilities

The ideal candidate would have expertise in in the development of processes for viral vector production to support engineered cell therapies. In addition, the candidate should have experience in managing teams and working with internal and external stakeholders in a highly matrixed fast paced environment.

  • Identify and implement solutions to address current technical challenges in viral vector (eg lentivirus and retrovirus) research and early development production processes to support engineered cell therapies
  • Serve as subject matter expert and support technology transfer as needed to viral vector CDMOs for cGMP clinical production
  • Support immediate cell therapy needs for gene delivery while innovating to enable next generation gene delivery technologies
  • Develop and/or improve methods in collaboration with research and analytical technologies to characterize viral vector production methods and primary cell transduction
  • Lead supply of viral vector materials to support research studies, analytical development, and CDMO tech transfer activities
  • Author and review technical and scientific documents including but not limited to ELN entries, study protocols and reports, SOPs and test methods
  • Establish strong relationships and collaborate closely across multiple functions, including discovery, Cell therapy, CMC and translational research within Obsidian as well as externally with Obsidians strategic partners.
  • Recruit talent as needed and manage Vector Technologies function with needed capabilities
  • Define agenda and manage experimental activities in the Vector Technologies function and ensure proper documentation

Minimum Qualifications

  • D. in a relevant discipline (eg chemical engineering, cellular and molecular biology, biotechnology)
  • Minimum of 5-7 years relevant industrial experience with prior direct experience in viral vector biology and/or production
  • Demonstrated track record with different gene delivery methodologies, such as lentivirus/ retrovirus/ AAV supporting early stage research and development of biologics
  • Subject matter expertise in mammalian cell culture, including adherent and suspension cell culture scale-up/down and stable cell line development
  • Subject matter expertise in viral vector production, including downstream purification and concentration methods (eg Tangential Flow Filtration)
  • Familiar with product characterization methods relevant to viral vectors (e.g. cell line/ primary cell transduction, titering, flow cytometry, qPCR/ ddPCR, ELISA, MSD, and western blot)
  • Experience managing laboratory scientists
  • Ability to work in a fast-paced, collaborative environment, working with minimal direction and able to manage workload based on changing priorities.
  • Demonstrated leadership skills and the ability to collaborate with and effectively influence others.

Preferred Qualifications

  • Experience in process development supporting early and/ or late stage development of biologics is highly desirable (cell therapy, gene therapy, vaccines, antibodies)
  • Experience in primary cell gene delivery, including cell types such as T cells, TILs, NK cells
  • Experience with Design of Experiment and application to process improvement
  • Familiarity with FDA and EMA guidance documents relevant to gene and cell therapy is a plus
  • Prior experience managing functional teams and representing function in cross-functional teams
Director of Intellectual Property

About the Company:

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s lead programs are in adoptive immune cell therapy, applying our cytoDRiVE™ technology to control the expression of proteins for enhanced therapeutic efficacy and safety.

We are looking for a motivated and experienced patent attorney or patent agent with a strong life sciences background to secure intellectual property protection and manage IP matters crucial for the success of a growing biotech company. As a Director at Obsidian, you will provide strategic counseling to the R&D organization and senior leadership team, provide IP support for business development activities, manage outside counsel, and develop patent portfolios that align with the company’s business needs.  This position reports to the SVP, IP & Legal Affairs.

This role is a unique opportunity at a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced biotech team. You will help us to continue to build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

 

Primary Responsibilities

  • Collaborate with the SVP, IP & Legal Affairs, and other internal partners to develop and execute global intellectual property strategies consistent with Obsidian’s business objectives and priorities.
  • Supervise outside counsel in the preparation and prosecution of patent applications, the drafting of legal opinions, and other matters as needed.
  • Perform patentability, validity and freedom to operate assessments for internal R&D programs and business development opportunities.
  • Counsel internal clients on IP matters, including identifying and protecting inventions and educating colleagues on global IP topics.
  • Conduct competitive intelligence and landscape analyses and collaborate with internal colleagues to mitigate third party IP risks.
  • Draft and negotiate nondisclosure, collaboration, service, licensing and other agreements involving the use, transfer or ownership of IP.
  • Assist in preparing and implementing IP policies and guidelines.

 

Required Qualifications and Skills

  • Registered to practice before the U.S. Patent & Trademark Office.
  • D. or equivalent from accredited law school and member in good standing of a Bar of at least one state or the District of Columbia. Patent agents with a strong corporate or law firm background will be considered.
  • S. or Ph.D. in genetics, molecular biology, immunology, microbiology or biochemistry.
  • Six or more years’ experience as a practicing patent attorney or patent agent in a law firm or biotech/pharmaceutical company.
  • Expertise in drafting and prosecuting patent applications in cell and gene therapies, nucleic acid-based therapeutics or biologics.
  • Proficient in performing landscape, patentability, validity and freedom to operate assessments.
  • Effective presentation, communication and interpersonal skills.
  • Demonstrated ability to manage multiple projects simultaneously in an organized and resourceful fashion.
Senior/ Principal Scientist Analytical Technologies

Obsidian Therapeutics is pioneering controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases. We are looking for a leader in our Technologies Center of Excellence to build additional Analytical Technology capabilities for Obsidian driving the development of the engineered cell therapy products in our pipeline targeting cancer. You will be a vital part of helping to achieve Obsidian’s vision by collaboratively translating innovative science into medical breakthroughs for patients.

The Senior Scientist/ Principal Scientist in Analytical Technologies is a key leadership role within our Technologies Center of Excellence function and will be responsible for leading the Analytical Technologies group. The Technologies Center of Excellence has the mission of advancing product development by delivering critical capabilities in core technologies and key reagents. The Analytical Technologies group is responsible for providing analytical protocols and data on reagents and controls for the development of engineered cell therapies. The individual in this role will work collaboratively  with the Vector Technologies, Cell Technologies and Protein Technologies groups to develop platform analytics to support viral vector production, construct screening and engineered cell therapies. You will have significant opportunity to have an impact to Obsidian’s broader development strategies and efforts.

Responsibilities

The candidate should have expertise in analytical development and characterization of engineered cell therapies and/ or viral vector vectors. The ideal candidate would have experience working with process development and CMC teams and qualifying analytical methods for early phase clinical trials. In addition, the candidate should have experience in managing teams and working with internal and external stakeholders in a highly matrixed fast paced environment.

  • Identify and implement solutions to address current technical challenges in the characterization of viral vectors (lentivirus and gamma-retrovirus) and engineered cell therapies
  • Serve as subject matter expert and support technology transfer and assay qualification at CDMOs for analysis of cGMP clinical production
  • Support immediate research and development needs while innovating to enable next generation analytics
  • Develop and/or improve methods in collaboration with research and vector technologies to characterize viral vector production methods and primary cell transduction (eg T cell, TIL, NK cell)
  • Develop, own and implement analytical platform, including new technologies, common reagents and controls, trending data, and protocols to support construct screening, research studies, research vector production, and CDMO tech transfer activities
  • Author and review technical and scientific documents including but not limited to ELN entries, study protocols and reports, SOPs and test methods
  • Establish strong relationships and collaborate closely across multiple functions, including Discovery, Cell therapy, CMC and translational research within Obsidian as well as externally with Obsidian’s strategic partners.
  • Recruit talent as needed and manage analytical technologies function with needed capabilities
  • Define agenda and manage experimental activities in the analytical technologies function and ensure proper documentation

Minimum Qualifications

  • D. in a relevant discipline (molecular biology, cell biology, biomolecular engineering, biotechnology or relevant field)
  • Minimum of 5-7 years relevant industrial experience with prior direct experience with analysis of viral vectors and/or cell therapies and experience required
  • Demonstrated track record with analytical development to support early stage development of biologics (cell therapy, gene therapy, vaccines, antibodies) with techniques focused on cell biology, immunology and molecular biology
  • Subject matter expertise in early stage analytical development, including cell line/ primary cell transduction/ transfection, multi-color flow cytometry/ FACS, qPCR/ ddPCR, ELISA, MSD, and western blot
  • Experience managing and training laboratory scientists on optimization and development of methods such as flow cytometry
  • Ability to work in a fast-paced, collaborative environment, working with minimal direction and able to manage workload based on changing priorities.
  • Demonstrated leadership skills and the ability to collaborate with and effectively influence others.

Preferred Qualifications

  • Experience in analytical development supporting early and/ or late stage development of biologics is highly desirable (cell therapy, gene therapy, vaccines, antibodies
  • Experience in primary cell gene delivery, including cell types such as T cells, TILs, NK cells
  • Familiarity with viral vector production and cell line engineering
  • Experience with Design of Experiment and application to analytical development
  • Familiarity with FDA and EMA guidance documents relevant to gene and cell therapy is a plus
  • Working knowledge of cGMP and quality systems requirements.
  • Experience authoring CMC sections of regulatory documents (IND/BLA)
  • Prior experience managing functional teams and representing function in cross-functional teams
Senior Associate Scientist/ Scientist Analytical Technologies

Obsidian Therapeutics is pioneering controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases. We are looking for a leader in our Technologies Center of Excellence to build additional Analytical Technology capabilities for Obsidian driving the development of the engineered cell therapy products in our pipeline targeting cancer. You will be a vital part of helping to achieve Obsidian’s vision by collaboratively translating innovative science into medical breakthroughs for patients.

 

Scope:

The Senior Associate Scientist/ Scientist in Analytical Technologies is a key role within our Technologies Center of Excellence function and will be responsible for developing and running assays within the Analytical Technologies group. The Technologies Center of Excellence has the mission of advancing product development by delivering critical capabilities in core technologies and key reagents. The Analytical Technologies group is responsible for providing analytical protocols and data on reagents and controls for the development of engineered cell therapies. The individual in this role will work collaboratively with others on the team as well as the Vector Technologies, Cell Technologies and Protein Technologies groups to develop platform analytics to support viral vector production, construct screening and engineered cell therapies.

Responsibilities

The ideal candidate would have expertise in in the characterization of cell therapies and/ or viral vector vectors. In addition, the candidate should have experience working in fast paced collaborative scientific teams.

  • Design, plan, and execute experiments in Analytical Technologies, working both independently and as part of a multidisciplinary team of researchers
  • Develop and/or improve methods in collaboration with research and vector technologies to characterize viral vector production methods and primary cell transduction (eg T cell, TIL, NK cell)
  • Support introduction of new analytical technologies, implementation of common reagents and controls, trending data, and protocols to support construct screening, research studies, research vector production, and CDMO tech transfer activities
  • Interpret results, troubleshoot technical hurdles, and propose solutions to the team
  • Maintain excellent records of experiments, including Electronic Notebook entries, authoring of protocols, test methods, and study reports
  • Collaborate effectively across Obsidian organization, present internally to project teams, management, and scientific teams

 

Minimum Qualifications

  • MS or Ph. D. in a relevant discipline (molecular biology, cell biology, biomolecular engineering, biotechnology or relevant field)
  • Minimum of 5-7 years (MS) or 1-3 years (PhD) relevant industrial experience with prior direct experience with analysis of viral vectors and/or cell therapies required
  • Demonstrated track record with analytical techniques focused on cell biology, immunology and molecular biology
  • Tissue culture of adherent and suspension cell lines, including transfection and viral transduction
  • Subject matter expertise in early stage analytical development, including methods such as cell line/ primary cell transduction/ transfection, multicolor flow cytometry/ FACS, qPCR/ ddPCR, ELISA, MSD, and western blot
  • Strong troubleshooting and communication skills, highly organized with strong record keeping and an ability to multi-task
  • Highly collaborative working style and ability to adapt in a fast paced, rapidly developing environment

 

Preferred Qualifications

  • Experience in analytical development supporting early and/ or late stage development of biologics is highly desirable (cell therapy, gene therapy, vaccines, antibodies)
  • Experience in primary cell gene delivery, including cell types such as T cells, TILs, NK cells
  • Familiarity with viral vector production and cell line engineering
  • Experience with Design of Experiment and application to analytical development
  • Familiarity with FDA and EMA guidance documents relevant to gene and cell therapy is a plus
Senior Research Associate / Senior Associate Scientist: Cellular Immunology

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s lead programs are in adoptive immune cell therapy, applying our cytoDRiVE™ technology to control the expression of proteins for enhanced therapeutic efficacy and safety.

We are looking for a talented, flexible, collaborative, dynamic scientist to join the department of Cell Therapy as key contributors to preclinical research supporting Cell Therapy program research and development.

This role is a unique opportunity to at a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced biotech team. You will help us to continue to build a transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

 

Primary Responsibilities:

  • Make independent intellectual and technical contributions to projects, while working on a collaborative team
  • Design, develop and apply cell-based immune assays, including engineering of human T and NK cells
  • Isolate immune cells from human blood and tissue and conduct ex vivo engineering, differentiation, characterization, and/or in vivo adoptive cell transfer studies
  • Perform ex vivo analysis of samples from in vivo adoptive cell transfer studies, including immunophenotyping and serum analysis
  • Independently design experiments, meticulously execute bench work, troubleshoot assays, analyze data, and communicate findings
  • Present results at internal meetings

 

Required Qualifications and Preferred Skills:

  • BS/MS with 3+ yrs experience in an industry setting (job title will depend on level of experience)
  • Ability to quickly learn and adapt to fast paced, rapidly changing start-up environment
  • Scientific rigor in the design, execution, analysis, and troubleshooting of scientific experiments
  • High level of motivation and ability to work both independently and collaboratively
  • Excellent organization, record keeping, multi-tasking, and communication skills
  • Demonstrated expertise in ex vivo immunology methods including T and NK cell genetic engineering (gene transfer or gene editing), functional assay development using techniques such as multi-color flow cytometry, cytotoxicity assays, and cytokine quantitation
  • Viral vector transduction of primary human immune cells would be highly valued
  • Cellular immunotherapy experience preferred
  • Experience with tumor infiltrating lymphocytes (TILs) would be a plus
  • Authorized to work in the US at the time of application
Director Quality Assurance (QA), GxP - Obsidian Therapeutics

About the Company:

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s lead programs are in adoptive immune cell therapy. Obsidian’s programs apply our CytoDriveTM technology in Cell Therapy products to control expression of proteins for enhanced therapeutic efficacy and safety.

We are looking for a highly talented, collaborative, and experienced Director of Quality Assurance (QA) to partner with Head of Regulatory Affairs (RA) and Quality Assurance in building a QA function.

This role is a unique opportunity to be a have a key role in a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced biotech team.  You will help us to continue to build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

 

SCOPE:

This newly created position reports to the Vice President of Regulatory Affairs and Quality Assurance and will partner with the V.P. to build a QA function within Obsidian. In this role, the Director of QA will lead planning and execution of establishing quality management systems and practices and perform/manage QA activities related to GxP with an initial emphasis on GMP. The position requires excellent communication skills, and a desire and willingness to work in a fast-paced entrepreneurial environment.

 

ACCOUNTABILITIES/RESPONSIBILITIES:

  • Develop and oversee a quality management system in compliance with regulations for GxP activities; lead implementation and ensure effectiveness across departments; collaborate with IT on electronic systems for GxP activities
  • Design, implement, and maintain QA and GxP compliance programs and infrastructure, including SOP development/maintenance, document control/change control processes, internal/external audits, deviation review and tracking, investigations, and corrective and preventative action
  • Manage training programs for internal staff and Obsidian representatives overseeing or performing GxP activities and serve as an in-house advisor on GxP compliance
  • Initiate continuous improvement activities, create/revise procedures/practices and specifications, and provide training on quality systems and procedures.
  • Perform vendor qualification and oversight, including CDMOs, GLP study testing facilities, Contract Reach Organizations supporting clinical activities; and maintain quality agreements
  • Enable sustainable compliance with international quality standards and applicable programs and initiatives; proactively identify compliance issues/risks, within the organization and with its external partners, and regularly report to management on compliance activities and findings
  • GMP specific responsibilities:
    • Effectively collaborate with internal technical manufacturing lead and manage all third parties contracted to perform GMP manufacturing activities to ensure full compliance.
    • Perform batch release activities and review reprocessing and rework procedures.
    • Oversee GMP testing to assure conformance with protocols, policies and GMP regulations.
    • Plan and conduct audits and inspection readiness of manufacturing and release sites. Manage product complaints and investigations for clinical supplies.

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

  • Bachelor’s degree in a life science required; Master’s Degree or PhD in scientific discipline a plus
  • Minimum 10 years of relevant work experience in biotechnology/pharmaceutical Quality Assurance
  • Solid and demonstrable knowledge of international GxP regulations and guidelines, industry practices, and experience implementing Quality Systems in a regulated environment
  • Ideal candidate will have broad experience in product development, regulatory compliance, GxP auditing
  • Strong organization and time management skills
  • Excellent attention to detail with an ability to perform critical review of various types of documents
  • Outstanding written and verbal communication skills
  • Ability to independently solve problems, lead projects, and influence teams
  • Experience identifying and evaluating risks, and executing efficient and effective mitigations
  • Demonstrated ability to work as a team player with multi-disciplinary project teams
  • Proficiency with commonly used word processing, database systems, document management and quality systems
  • Experience with cell or gene therapy a plus