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Our Culture

If you are considering a job with us, please take a few minutes to review our values. Operating with Integrity, Respect, Quality and Innovation are non-negotiable. At Obsidian, we embody the following values (obviously, we have a thing for alliterations):

Adaptability & Agility

We catalyze our evolution through continuous learning and sharing

Efficiency & Efficacy

We maximize our capabilities by leveraging each other’s expertise

Passion & Purpose

Our patients are waiting

Resilience & Results

We tenaciously overcome challenges to deliver meaningful outcomes

Camaraderie & Chemistry

We celebrate trust and community

 

“Obsidian provides the opportunity to collaborate in teams, with an open exchange of ideas and learnings. This transparency and curiosity fosters individual professional development while advancing the team toward developing new therapeutics with the potential to impact patient lives.”


Jennifer Gori, Ph.D.
Director of Program Strategy
 

We always welcome dedicated and talented applicants to apply to join our growing team. Please send resumes to jobs@obsidiantx.com; include a cover letter that highlights your qualifications and matches our requirements.

Open Positions

Associate Director, Business Development

About the Company:

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s lead programs are in adoptive immune cell therapy, applying our cytoDRiVE™ technology to control the expression of proteins for enhanced therapeutic efficacy and safety.

We are looking for a highly talented, motivated, and collaborative individual to help drive our business strategy forward and execute against our growth plans. As an early hire at a fast-paced biotech company, you will have significant exposure to senior management and will contribute to critical initiatives spanning business development, strategy, new product planning, communications, competitive intelligence, and alliance management.  This position reports directly to the VP of Business Development.

This role is a unique opportunity to at a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced biotech team. You will help us to continue to build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

 

ACCOUNTABILITIES/RESPONSIBILITIES

Business Development

  • Work closely with the VP of Business Development to support the sourcing, evaluation, negotiation, and execution of partnering transactions
  • Manage due diligence processes including the preparation, organization, and maintenance of supporting documents and data
  • Support alliance management of existing corporate and academic collaborations

Corporate Strategy

  • Support strategic planning process by collecting cross-functional input, performing scenario analyses, and maintaining and updating planning documents
  • Contribute to new product planning by conducting market reviews, developing commercial assessments, and collecting feedback from internal & external parties
  • Partner with cross-functional colleagues to assist in the preparation of materials for BOD and investor meetings

 

 

Business Operations

  • Contribute to communications and competitive intelligence strategy
  • Develop and maintain corporate communication materials such as slide presentations, website content, and press releases
  • Perform competitive intelligence on the cell and gene therapy landscape

 

 

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

  • A., B.S., or M.S required; scientific field of study or graduate degree (MBA, MD, PhD) preferred
  • 3-5 years’ experience with the biotech / pharmaceutical industry; business development, corporate or commercial strategy, investment banking, consulting or related roles will be considered
  • Proficiency in Powerpoint, Word and Excel, including financial modeling
  • Excellent oral and written communication skills, with ability to flex between scientific / technical detail and big-picture strategy
  • Ability to work independently and multitask in an entrepreneurial environment
  • Demonstrated strong interpersonal, teamwork, analytical, and organizational skills
  • History of achievement and excellence in previous roles
Sr. Scientist, Cell Therapy

About the Company:

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s lead programs are in adoptive immune cell therapy, applying our cytoDRiVE™ technology to control the expression of proteins for enhanced therapeutic efficacy and safety.

We are looking for a talented, flexible, collaborative, dynamic scientist to join the department of Cell Therapy as key contributors to preclinical research supporting Cell Therapy program research and development.

This role is a unique opportunity to at a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced biotech team. You will help us to continue to build a transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

Primary Responsibilities:

  • Lead preclinical proof of concept research activities toward the development of cell therapy products
  • Mentor and/or mentor a team of scientists/research associates in the design, execution and analysis of experiments that support programs
  • Design, develop and apply cell-based immune assays, including engineering of human T and NK cells
  • Make independent, intellectual, and technical contributions to projects, while working on a collaborative team
  • Isolate immune cells from human blood and tissue and conduct ex vivo engineering, differentiation, characterization, and/or in vivo adoptive cell transfer studies
  • Independently design experiments, meticulously execute bench work, troubleshoot assays, analyze data, and communicate findings
  • Present results at internal meetings

Required Qualifications and Preferred Skills:

  • PhD in Immunology or a related field with 3+ years of industry experience
  • Ability to quickly learn and adapt to fast paced, rapidly changing start-up environment
  • Scientific rigor in the design, execution, analysis, and troubleshooting of scientific experiments
  • Experience leading and driving research projects
  • Highly motivated team contributor, with ability to work independently and collaboratively
  • Excellent organization, record keeping, multi-tasking, and communication skilled
  • Demonstrated expertise in ex vivo immunology methods including T and NK cell genetic engineering (gene transfer or gene editing), functional assay development using techniques such as multi-color flow cytometry, cytotoxicity assays, cytokine quantitation
  • Experience with tumor infiltrating lymphocytes (TIL) preferred
  • Viral vector transduction of primary human immune cells preferred
  • Cellular immunotherapy experience preferred
  • Authorized to work in the US at the time of application
Associate Director, Cell Therapy

About the Company:

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s lead programs are in adoptive immune cell therapy, applying our cytoDRiVE™ technology to control the expression of proteins for enhanced therapeutic efficacy and safety.

We are looking for a talented, experienced scientific leader to join the department of Cell Therapy as a key contributor to preclinical research supporting Cell Therapy program research and development. As an Associate Director at Obsidian, you will have a key leadership and a program-based role.  This role will require both matrix management and program research leadership.

This role is a unique opportunity to at a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced biotech team. You will help us to continue to build a transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

Primary Responsibilities:

  • Lead preclinical proof of concept research activities toward the development of cell therapy products
  • Mentor and/or mentor a team of scientists/research associates in the design, execution and analysis of experiments that support programs
  • Design, develop and apply cell-based immune assays, including engineering of human TIL and NK cells
  • Make independent, intellectual, and technical contributions to projects, while working on a collaborative team
  • Isolate immune cells from human blood and tissue and conduct ex vivo engineering, differentiation, characterization, and/or in vivo adoptive cell transfer studies
  • Independently design experiments, meticulously execute bench work, troubleshoot assays, analyze data, and communicate findings
  • Present results at internal and external meetings

Required Qualifications and Preferred Skills:

  • PhD in Immunology or a related field with 3+ years of experience postdoctoral training, strong publication record, and preference for 7+ years of industry experience
  • Ability to quickly learn and adapt to fast paced, rapidly changing start-up environment
  • Scientific rigor in the design, execution, analysis, and troubleshooting of scientific experiments
  • Experience leading and driving research projects to IND
  • Highly motivated team contributor, with ability to work independently and collaboratively
  • Excellent organization, record keeping, multi-tasking, and communication skilled
  • Demonstrated expertise in ex vivo immunology methods including T and NK cell genetic engineering (gene transfer or gene editing), functional assay development using techniques such as multi-color flow cytometry, cytotoxicity assays, cytokine quantitation
  • Experience with tumor infiltrating lymphocytes (TIL) preferred
  • Viral vector transduction of primary human immune cells preferred
  • Cellular immunotherapy experience preferred
  • Authorized to work in the US at the time of application
Obsidian Therapeutics Associate Director, IT Operations, Security and Quality Systems

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s lead programs are in adoptive immune cell therapy. Obsidian’s programs apply our CytoDriveTM technology in Cell Therapy products to control expression of proteins for enhanced therapeutic efficacy and safety.

This role is a unique opportunity to be a contributor in a well-funded startup with blue chip investors, a major collaboration in place, field-leading founders and advisors, and a highly experienced startup team. You will help us continue to build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need.

Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

Responsibilities:

Security

  • Manage development, implementation and operation of Obsidian’s information security framework, including developing underlying policies, standards, guidelines and procedures.
  • Lead the prompt response to all security incidents and provide thorough post-event analyses.
  • Plan and develop user security awareness, and training and education programs to safeguard information.
  • Participate in special projects, including disaster recovery, as they relate to information security.
  • Assist in establishing and managing information governance initiatives to implement appropriate policies and processes for the management and protection of Obsidian’s information assets.

Quality & Compliance

  • Perform and support all quality-related activities associated with computerized systems including periodic reviews, exception management (deviation / CAPA), and change and risk management.
  • Support internal and external audits as the IT Quality point of contact.
  • Ensure IT solutions and system are in compliance with all regulatory requirements affecting Obsidian’s business.
  • Manage the selection, implementation and operation of GxP solutions ensuring alignment with business need, compliance with appropriate regulations, and appropriate support and licensing.

Strategy

  • Work with the Head of IT to develop strategic roadmap that supports and aligns with Obsidian’s long-term plans, ensuring solutions deliver value and advance company goals.
  • Leverage business analysis and project management skills to plan and execute projects that align with the strategic roadmap, ensuring projects deliver on well-defined requirements and are completed on time and within established budgets.

 

 

 

Operations

  • Oversee IT Operations, including EUS, network, and infrastructure (both physical and cloud hosted).
  • Manage directory services and device management, including active directory, azure AD, Single Sign On, and InTune.
  • Manage IT vendor relationships, establishing a strong spirit of partnership, shared goals, and continuous improvement.

 

Required Qualifications and skills:

  • 8 years of experience working in an IT organization
  • 5-7 years of biotech, pharmaceuticals or life science industry experience
  • Experience with O365 is required, M365 preferred
  • Prior experience working with content management, collaboration technologies and digital platforms
  • Demonstrated ability to lead complex cross-functional technology projects
  • Experience building content and information architectures.
  • Experience with implementation and management of Quality, Clinical and Regulatory systems required
  • Excellent communication skills and the ability to present technical and non-technical information to mixed audiences.
  • Working knowledge of common SDLC frameworks, including experience leading design, development, and testing activities.
  • Knowledge of computer systems validation processes as well as regulations governing electronic records and electronic signatures in FDA regulated industries (21CFRp11).
  • Experience in vendor management
  • Previous experience managing day-to-day operations for content and collaboration services, including management of both internal teams and external vendor relationships for managed or hosted services.
  • A clear understanding of relevant information security governance, technical and security standards, and regulations.
  • Familiar with cloud security, platforms, and services, including an understanding of current security offerings from leading cloud service providers, and their applicability to securing a SaaS enterprise security environment.
  • Knowledge of networking and network security.

 

To apply, please contact jobs@obsidiantx.com

 

Senior Research Associate/Associate Scientist (New Technology Discovery)

About the Company:

Obsidian Therapeutics is a biotechnology company that is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety.

 

Scope:

We are looking for a highly motivated Senior Research Associate or Associate Scientist with expertise in synthetic biology and cell engineering to join our Discovery team.  The successful candidate will be responsible for the engineering and testing of new technologies for regulating gene expression as part of a team developing Obsidian’s next generation CytoDriveTM platform.  The candidate will work alongside a multidisciplinary team of immunologists, cell biologists, and molecular biologists to deliver controllable cellular therapies. This role is a unique opportunity to be a scientific contributor in a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced startup team. You will help us build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.

 

 Key Responsibilities:

  • Engineer cell lines with regulated gene expression systems using a range of delivery methods including transfection, viral transduction, and homology directed repair.
  • Develop assays to test performance of engineered cell lines using state of the art techniques including NGS, microscopy, quantitative PCR, western blot, ELISA, and FACS
  • Design, plan, and execute experiments to test performance of regulated gene expression systems in relevant pre-clinical models of disease working both independently and as part of a multidisciplinary team of researchers
  • Interpret results, troubleshoot technical hurdles, and propose solutions to the team
  • Maintain excellent records of experiments
  • Collaborate effectively across Obsidian organization, present internally to project teams, management and scientific teams.

 

Minimum Qualifications:

  • Bachelor’s or Master’s degree in biology or relevant field with Masters and 2+ years of experience or Bachelor’s and 5+ years of experience in biotech/pharma setting
  • Tissue culture of adherent and suspension cell lines, including transfection and viral transduction
  • Experience with genome editing and associated analytical methods.
  • Analysis of sequencing data using Benchling, DNAstar, Geneious, or similar informatics software
  • Molecular/biochemical assays for cell line analysis such as quantitative PCR, western blot, ELISA, and FACS
  • Strong troubleshooting and communication skills, highly organized with strong record keeping and an ability multi-task
  • Highly collaborative working style and ability to adapt in a fast paced, rapidly developing environment

 

Preferred Qualifications:

  • Experience working in the cell and gene therapy field is highly desirable.
  • Previous experience in synthetic biology or regulated gene expression
  • Engineering primary cells by viral and/or non-viral gene delivery