Shyam Subramanian, Ph.D.

Shyam Subramanian, Ph.D., is Obsidian’s Chief Technical officer and heads technical development, manufacturing and quality. In this role he leads all aspects of CMC, including process development, analytical development, external manufacturing and supply chain for Obsidian’s product portfolio. He also is responsible for the quality assurance function that supports all of Obsidian’s GxP activities. Dr. Subramanian brings over 25 years of post-discovery through commercialization product development experience in complex biologics, including products in the cell and gene therapy space. Prior to joining Obsidian, Dr. Subramanian was the Head of Cell Therapy Development & Manufacturing at Casebia Therapeutics, leading the CMC development of several novel CRISPR-edited T-cell therapy product candidates for autoimmune diseases. Prior to Casebia, Dr. Subramanian spent over 20 years in biopharma—Merck, Chiron, Teva and Johnson & Johnson—with responsibility for early- and late-stage process development, technology transfer and manufacturing support for viral and bacterial vaccines, antibodies and gene therapy vectors. Dr. Subramanian holds a Ph.D. in chemical and biomolecular engineering from the University of Pennsylvania.