Collaborators & Investors
Chemical control of protein stability and function in living mice.
Nat Med. 2008 Oct;14(10):1123-7. doi: 10.1038/nm.1754. Epub 2008 Sep 28.
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules.
Cell. 2006 Sep 8;126(5):995-1004.
Genetically engineered tumor-infiltrating lymphocytes (cytoTIL15) exhibit IL2- independent persistence and anti-tumor efficacy against melanoma in vivo
SITC 2021 (November)
cytoTIL15: A novel TIL therapy for melanoma with superior potency and enhanced persistence without IL2 to improve safety and efficacy and expand patient eligibility
ESMO 2021 (September)
cytoTIL™ therapy engineered with mbIL15 demonstrates enhanced in vivo persistence in the absence of IL2
ASGCT 2021 (May)
Regulated Membrane-Bound IL15 Drives Controlled Expansion of Tumor Reactive Lymphocytes
ASGCT 2020 (May)
Regulation of CD40 Ligand Transgene Expression in Human CAR-T Cells Using FDA Approved Drugs
ASGCT 2019 (May)
CAR-Ts Armored with Small Molecule-regulated IL12 or CD40L Cassettes for Enhanced Activity Against Solid Tumors
AACR 2019 (March)
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