Obsidian TherapeuticsObsidian Therapeutics
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Publications

AACR (April 2025)

Trial in progress: Phase 1/2 study of OBX-115 engineered tumor-infiltrating lymphocyte (TIL) cell therapy in patients with advanced solid tumors

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AACR (April 2025)

Spatiotemporally regulated expression of membrane-bound interleukin 12 (mbIL12) for armored adoptive cell therapy (ACT) shows strong antitumor activity in syngeneic solid tumor models without overt toxicity

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Molecular Therapy

IL2-independent expansion, persistence, and antitumor activity in TIL expressing regulatable membrane-bound IL15

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Cytotherapy

Entering a New Era of TIL Cell Therapy Innovation

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Communications Biology

Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells

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SITC (November 2024)

Antigen-responsive promoters coupled with cytoDRiVE® technology provides tight spatiotemporal regulation for tumor-infiltrating lymphocytes (TIL) expressing membrane-bound IL12 (mbIL12)

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SITC (November 2024)

Feasibility of using core needle biopsy technique for minimally invasive tumor procurement to generate OBX-115 TIL from NSCLC tumors

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SITC (November 2024)

Engineered tumor-infiltrating lymphocytes (TIL) with membrane-bound IL15 (mbIL15) and LIGHT (TNFSF14) generate significant antitumor efficacy in fibrotic tumor models

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Obsidian Therapeutics
  • About Us
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Our programs, including OBX-115, and cytoDRIVE® Platform are investigational and have not been approved by the FDA or any other regulatory agency.

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