Research Associate/Associate Scientist Cellular Immunology

Obsidian Therapeutics is a biotechnology company developing next-generation cell and gene therapies with pharmacologic operating systems. Based upon founding work on destabilizing domains by Professor Thomas Wandless, a leading researcher in chemical and systems biology, Obsidian’s lead programs are CAR-T products that incorporate controllable functions for enhanced safety and efficacy.

We are looking for a highly talented, flexible, collaborative, dynamic Associate Scientist to be a key driver of our preclinical research efforts. This role is a unique opportunity to be a partner and scientific contributor in a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced startup team. You will help us build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.


Primary Responsibilities:

  • Make independent, intellectual, and technical contributions to Obsidian projects, while working on a collaborative team
  • Isolate T cells, NK cells, and monocytes from murine splenocytes and human blood for ex vivo engineering, differentiation, characterization and in vivo adoptive transfer studies
  • Design, develop, and execute in vitro and ex vivo cell based assays using cell lines, human primary cells, and human and murine whole blood
  • Develop and evaluate biomarker strategies using murine and human ex vivo tissues and serum
  • Independently design experiments, meticulously execute bench work, troubleshoot assays, analyze data, and communicate findings
  • Present results at internal meetings


Required Qualifications and Skills:

  • BS/MS with 3+ yrs experience in an industry setting; immunology or immuno-oncology research preferred (job title will depend on level of experience)
  • Ability to quickly learn, and adapt in a fast paced, rapidly developing environment. Experience working in multiple projects simultaneously is a plus
  • Demonstrated expertise in ex vivo immunology studies and functional T, NK, and myeloid cell assay development using techniques such as multi-color flow cytometry, Luminex, MSD, ELISA and ELISpot
  • Experience with lentiviral or retroviral transduction of primary human & murine cells would be a plus
  • Competency in cell biology, molecular biology and protein chemistry techniques, including qPCR and western blotting would be highly valued
  • High level of motivation and ability to work both independently and on collaborative teams
  • Strong analytical and troubleshooting skills with flawless record keeping and multi-tasking abilities
  • Excellent organization and communication skills
  • Authorized to work in the US at the time of application


No Employment Agencies please, the Company is not responsible for any fees related to candidates that are unsolicited.


Posted: 6/16/19