Research Associate/Senior Research Associate Gene Delivery

Obsidian Therapeutics is a biotechnology company developing next-generation cell and gene therapies with pharmacologic operating systems. Based upon founding work on destabilizing domains by Professor Thomas Wandless, a leading researcher in chemical and systems biology, Obsidian’s lead programs are CAR-T products that incorporate controllable functions for enhanced safety and efficacy.

We are looking for a talented, diligent, curious and collaborative Senior Research Associate to leverage a breadth of viral and non-viral gene transfer techniques to help us enable innovative cell and gene therapies in oncology and other diseases. This role is a unique opportunity to be a partner and scientific contributor in a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced startup team. You will help us build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.


Primary Responsibilities:

  • Maintain cell cultures and cell banks; produce, concentrate, and characterize lentiviral, retroviral, and non-viral vectors for gene delivery into cell lines and primary cells.
  • Organize and execute laboratory experiments, according to high scientific standards.
  • Work with project teams to collect and prioritize production requests; organize and maintain inventory of lentiviral and retroviral stocks.
  • Maintain accurate and detailed laboratory notebook and documentation.
  • Follow established safety policies, procedure, and practices.
  • Prepare and present work results for internal and external meetings and conferences.
  • Assist in molecular and cell biology experiments.


Required Qualifications and Skills:

  • BS/MS with 1+ years of biotech/pharmaceutical industry experiences.
  • Required: 1+ years experience in mammalian cell culture (cell line and/or primary cells).
  • Strongly preferred: 1+ years of virus (AAV and/or lentiviral vector) production experience.
  • Comfortable working in BSL2+ laboratory environments, including producing large scale lentiviruses or retro viruses.
  • Experience with molecular biology and cell biology techniques a plus.
  • Experience in immunology / immuno-oncology a plus.
  • Be dependable, with strong analytical skills, and highly organized with excellent documentation skills and multi-tasking abilities.
  • Enthusiastic team worker with strong interpersonal skills and commitment to work both independently and collaboratively in fast paced environment.
  • Must currently have authorization to work in the United States at the time of application


No Employment Agencies please, the Company is not responsible for any fees related to candidates that are unsolicited.


Posted: 6/18/2019