Scientist/Senior Scientist In Vivo Cancer Immunology

Obsidian Therapeutics is a biotechnology company developing next-generation cell and gene therapies with pharmacologic operating systems. Based upon founding work on destabilizing domains by Professor Thomas Wandless, a leading researcher in chemical and systems biology, Obsidian’s lead programs are CAR-T products that incorporate controllable functions for enhanced safety and efficacy. We are looking for a highly talented, flexible, collaborative, dynamic immunologist to be a key driver of our preclinical research efforts. This role is a unique opportunity to be a partner and scientific contributor in a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced startup team. You will help us build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.


Primary Responsibilities:

  • Develop, implement, and coordinate immuno-oncology preclinical tumor models using adoptive transfer of T cells and small molecule dosing for target validation, candidate selection, and IND-enabling studies
  • Develop and implement in vivo methodologies for the advancement of Obsidian technology, including characterization of immune cells, efficacy and biomarker assessment, and PK/PD analysis
  • Supervise the design of experiments, ensure meticulous execution of bench work, analyze data, troubleshoot, and communicate findings
  • Work effectively as a team member with strong interpersonal skills and commitment to working collaboratively in a fast paced environment


Required Qualifications and Skills:

  • PhD in Immunology, Cancer Biology, or related field with preference for postdoctoral experience and/or experience in biotech/pharma setting
  • Expertise with mouse in vivo tumor models, with preference for experience with syngeneic tumor models and evaluation of immune-based therapies
  • Expertise with animal handling, IV, IP, and oral dosing of small molecules, adoptive cell transfer, and tissue harvesting
  • Comprehensive understanding of and experience with PK/PD analysis
  • Strong analytical, troubleshooting and excellent communication skills, highly organized with flawless record keeping and multi-tasking abilities
  • Highly collaborative working style, passion for immuno-oncology, and ability to adapt in a fast paced, rapidly developing environment
  • Authorized to work in the US at the time of application


No Employment Agencies please, the Company is not responsible for any fees related to candidates that are unsolicited.


Posted: 6/14/19