Senior Scientist/Principal Scientist Cellular Immunology

Obsidian Therapeutics is a biotechnology company developing next-generation cell and gene therapies using synthetic biology approaches. Based upon founding work on destabilizing domains by Professor Thomas Wandless, a leading researcher in chemical and systems biology, Obsidian’s lead programs are CAR-T products that incorporate controllable functions for enhanced safety and efficacy.

We are looking for a highly talented, flexible, collaborative, and dynamic immunologist to be a key driver of our preclinical research efforts. This role is a unique opportunity to be a partner and scientific contributor in a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced startup team. You will help us build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to jobs@obsidiantx.com.


Primary Responsibilities:

  • Lead preclinical immunology assessments of our cell therapy products to select drug candidates for clinical testing
  • Manage and mentor a team of junior scientists in the execution of experiments to support cell therapy programs
  • Design, develop, and execute in vitro and ex vivo cell based immune assays, including engineering of primary T cells and assessment of antigen presenting cell functions
  • Make independent, intellectual, and technical contributions to Obsidian projects, while working on a collaborative team
  • Independently design experiments, meticulously execute bench work, troubleshoot assays, analyze data, and communicate findings
  • Present results at internal and external meetings


Required Qualifications and Skills:

  • PhD in immunology, immuno-oncology, cancer biology or related field with postdoc experience and a preference for 2+ years of industry experience
  • Demonstrated expertise in in vitro/ex vivo immunology studies, including functional T cell and dendritic cell assay development using techniques such as primary cell isolation, multi-color flow cytometry, cytotoxicity assays, and cytokine quantitation
  • Expertise in antigen presenting cell biology and/or CD40L biology is preferred
  • Experience with lentiviral & retroviral transduction of primary human or murine cells would be a plus
  • Managerial experience preferred
  • Ability to quickly learn and adapt in a fast paced, rapidly developing environment
  • Creativity and intellectual rigor with experience in driving research projects, including the design, execution, and analysis of experiments
  • High level of motivation and ability to work both independently and in collaborative teams
  • Flawless record keeping and multi-tasking abilities
  • Excellent organization and communication skills
  • Authorized to work in the US at the time of application


No Employment Agencies please, the Company is not responsible for any fees related to candidates that are unsolicited.


Posted: 6/16/19