Senior Scientist/Scientist PK/PD Modeling Specialist

Obsidian Therapeutics is a biotechnology company developing next-generation cell and gene therapies with using synthetic biology approaches. Based upon founding work on destabilizing domains by Professor Thomas Wandless, a leading researcher in chemical and systems biology, Obsidian’s lead programs are engineered T cell products (CART and TCR T cells) that utilize small molecule drugs to control function for enhanced safety and efficacy. We are looking for a highly talented, flexible, collaborative, dynamic leader to create a key functional area to translate our research efforts to the clinic.

Obsidian products use FDA-approved small molecule drugs to trigger the production of therapeutic proteins within living cells. The qualified candidate will use his/her PK/PD modeling expertise to inform study design and interpretation in pre-clinical mouse models of anti-tumor cell therapy. A thorough understanding of small molecule pharmacology is essential for this individual to build and refine preclinical experimental designs that can be used for clinical translation.

This role is a unique opportunity to be a partner and scientific contributor in a well-funded startup with blue chip investors, field-leading founders and advisors, and a highly experienced startup team. You will help us build a dynamic, passionate, collaborative, transparent and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Located in an energetic environment in the heart of Cambridge, Obsidian is an equal opportunity employer offering a competitive salary and benefits package. Resumes can be sent to

Primary Responsibilities:

  • Apply expertise in PK/PD modeling to guide preclinical evaluation of small molecule-dependent cell therapy products
  • Make human dose predictions through empirical and model-based interspecies scaling of PK/PD
  • Contribute to the design, analysis, and interpretation of in vivo efficacy and toxicity studies
  • Collaborate extensively with project teams, in vivo pharmacology, and preclinical discovery to guide decision making on small molecule dose selection and scheduling, and other relevant parameters that impact preclinical study design
  • Distill findings to communicate effectively with key stakeholders
  • Prepare submissions for patent filings
  • Prepare components of regulatory filings as needed
  • Manage relationships with CROs and vendors to extend capabilities

Required qualifications and Skills:

  • Ph.D. (or equivalent degree) with preference for >2 years of industry experience in Pharmacology, Pharmaceutical Sciences, or related discipline
  • A thorough knowledge of PK principles and experimental approaches Proficiency in PK/PD modeling software, such as WINNONLIN, MATLAB, Phoenix, ADAPT and NONMEM
  • Proficiency in PBPK modeling software, such as Gastroplus, SimCYP
  • Experience in small molecule drug discovery in Oncology
  • Knowledge of cell therapy, particularly CART cell therapy, or biologics is a plus
  • Strong statistics/applied mathematics/computer science background is preferred
  • Strong critical, scientific, and strategic thinking skills. Strong problem solving and decision-making abilities.
  • Strong communication (verbal and written) skills. Ability to meet aggressive timelines.
  • Authorized to work in the US at the time of application

No Employment Agencies please, the Company is not responsible for any fees related to candidates that are unsolicited.

Posted: 6/14/19