Shyam Subramanian, Ph.D.

Shyam Subramanian, Ph.D.

Dr. Shyam Subramanian is Obsidian's Senior Vice President, Technical Operations and COE, where he leads all aspects of CMC, including process development, analytical development and manufacturing for Obsidian’s product portfolio. Dr. Subramanian brings to Obsidian over 20 years of post-discovery through commercialization product development experience in biologics, including products in the cell and gene therapy space. Prior to joining Obsidian, Dr. Subramanian was the Head of Cell Therapy Development & Manufacturing at Casebia Therapeutics, leading the CMC development of several novel CRISPR-edited T-cell therapy product candidates for autoimmune diseases. Prior to Casebia, Dr. Subramanian spent 20 years in biopharma—Merck, Chiron, Teva and Johnson & Johnson—with responsibility for early- and late-stage process development, technology transfer and manufacturing support for viral and bacterial vaccines, antibodies, and gene therapy vectors. Dr. Subramanian holds a Ph.D. in Chemical and Biomolecular Engineering from the University of Pennsylvania.



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