Obsidian Therapeutics
Expanding the reach of TIL therapy
We are a biotechnology company pioneering engineered tumor infiltrating lymphocyte (“TIL”) therapies to deliver transformative outcomes for patients suffering from solid tumor malignancies.
We engineer cytoTIL™ therapies using our proprietary cytoDRiVE® platform technology to express regulated therapeutic proteins to enhance anti-tumor activity.
OUR LEAD CLINICAL PROGRAM
OBX-115, A cytoTIL15™ Cell Therapy
Conventional TIL therapy has led to durable clinical responses in some patients with metastatic melanoma and non-small cell lung cancer, however the widespread clinical benefit has been limited due to efficacy challenges and toxicity concerns associated with required IL2 regimens.
We are advancing a pipeline of novel, engineered cytoTIL therapies to overcome many of these challenges and deliver safer, more effective TIL therapies for more patients.
Our lead clinical program, cytoTIL15 cell therapy (OBX-115), is an engineered TIL product armed with membrane-bound IL15 (mbIL15) to drive improved efficacy, including magnitude and duration of response. By replacing IL2 with mbIL15, cytoTIL15 cell therapy also eliminates the need for concomitant IL2 therapy, a toxic and costly requirement for conventional TILs.
Our Pipeline
cytoTIL
DISCOVERY
PRECLINICAL
PHASE 1
PHASE 2
PHASE 3
OBX-115 Melanoma (single center study)
PHASE: IND Enabling
COMPLETED ENROLLMENT:
NCT05470283
OBX-115
Next-Generation TIL Undisclosed
PHASE: Discovery
cytoDRiVE® PLATFORM
Our proprietary cytoDRiVE® platform leverages drug responsive domains (DRDs) to control protein function using an FDA-approved small molecule.
For a particular protein of interest, Obsidian engineers a gene cassette with a DRD tag, which is then packaged and inserted into the cell. The cell produces fusion protein consisting of the protein to be regulated, fused to a DRD, which is stabilized in the presence of a small molecule ligand. The stabilized fusion protein can be expressed intracellularly, membrane-bound or secreted. In the absence of the small molecule ligand, the DRD assumes a disordered conformation that is recognized by the quality control mechanisms of the cell, resulting in degradation of the fusion protein by the proteasome.
Obsidian has a growing library of internally discovered DRDs of varying sizes and purposes, and Obsidian’s cytoDRiVE® Discovery Platform enables rapid optimization of tunable and functional proteins. We have developed an extensive synthetic biology engineering toolkit to optimize protein functionality in any cell type, including but not limited to, type I/II membrane proteins, membrane-tethered cytokines, intracellular proteins, secreted proteins and genome editing proteins.
